Prediction and Classification of Ovarian Cancer using Enhanced Deep Convolutional Neural Network

Prediction and Classification of Ovarian Cancer using Enhanced Deep Convolutional Neural Network

  IJETT-book-cover           
  
© 2022 by IJETT Journal
Volume-70 Issue-3
Year of Publication : 2022
Authors : Kokila. R. Kasture, Dharmaveer Choudhari, Pravin N. Matte
https://doi.org/10.14445/22315381/IJETT-V70I3P235

How to Cite?

Kokila. R. Kasture, Dr. Dharmaveer Choudhari, Pravin N. Matte, "Prediction and Classification of Ovarian Cancer using Enhanced Deep Convolutional Neural Network," International Journal of Engineering Trends and Technology, vol. 70, no. 3, pp. 310-318, 2022. Crossref, https://doi.org/10.14445/22315381/IJETT-V70I3P235

Abstract
For the prediction and classification of Ovarian cancer`s four subtypes using histopathological pictures, this article uses a deep convolutional neural network (DCNN). With a dismal survival rate, Ovarian Cancer is the fifth most common and most aggressive kind of gynecologic cancer. Serous, mucinous, endometroid, and clear cell are the four major subtypes of ovarian epithelial cancer. A new trend in medical picture analysis is the use of computers to assist in the detection of various diseases such as cancer, brain tumors, seizures, and Alzheimer`s. An improved DCNN-based architecture for detecting benign and malignant cells has been developed and implemented in this paper, as shown in the figure. A subtype can be added if it is malignant. The researchers used 500 histopathological pictures from The Cancer Genome Atlas (TCGA-OV) collection, which had been made publically available, to create a total of 24,742 new images. By augmenting the photos used as training data, the proposed classification model, called KK-Net, went from 75% to 91% accuracy. This model`s performance was evaluated using the AUC-ROC curve (Area under the Curve - Receiver Operating Characteristics) statistical analysis approach. An AUC-ROC curve value of 95 percent was reached on average. On top of that, we used AlexNet, VGG-16, VGG-19, and GoogleNet to test the suggested model`s performance against the state-of-the-art approaches. Pathologists will be able to detect ovarian cancer in its earliest stages thanks to this newly established unique design, which can serve as a standard for predicting and classifying the disease.

Keywords
Artificial Intelligence, Machine learning, Predictive methods, Supervised learnings, Image processing.

Reference
[1] Cancer, Who.int. [Online]. Available: www.who.int/news-room/fact-sheets/detail/cancer.
[2] Cancer.org. [Online]. Available: www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2021/cancer-facts-and-figures-2021.pdf.
[3] L. A. Torre, B. Trabert, C. E. DeSantis, K. D. Miller, G. Samimi, et al., Ovarian Cancer Statistics, 2018: Ovarian Cancer Statistics, 2018, CA: A Cancer Journal for Clinicians. 68(4) (2018) 284–296.
[4] G. Chornokur, E. K. Amankwah, J. M. Schildkraut, and C. M. Phelan, Global Ovarian Cancer Health Disparities, Gynecologic Oncology. 129(1) (2013) 258–264.
[5] A. El-Nabawy, N. El-Bendary, and N. A. Belal, Epithelial Ovarian Cancer Stage Subtype Classification using Clinical and Gene Expression Integrative Approach, Procedia Computer Science. 131 (2018) 23–30.
[6] L. Zhang, J. Huang and L. Liu, Improved Deep Learning Network Based in Combination with Cost-Sensitive Learning for Early Detection of Ovarian Cancer in Color Ultrasound Detecting System, Journal of Medical Systems. 43(8) (2019) 251.
[7] M. Wu, C. Yan, H. Liu, and Q. Liu, Automatic Classification of Ovarian Cancer Types from Cytological Images using Deep Convolutional Neural Networks, Bioscience Reports. 38(3) (2018) BSR20180289.
[8] M. Shibusawa, R. Nakayama, Y. Okanami, Y. Kashikura, N. Imai, et al., The Usefulness of a Computer-Aided Diagnosis Scheme for Improving the Performance of Clinicians to Diagnose Non-Mass Lesions on Breast Ultrasonographic Images, Journal of Medical Ultrasonics. 43(3) (2016) 387–394.
[9] S. J. Chen, C. Y. Chang, K. Y. Chang, J. E. Tzeng, Y. T. Chen et al., Classification of the Thyroid Nodules Based on Characteristic Sonographic Textural Feature and Correlated Histopathology using Hierarchical Support Vector Machines, Ultrasound in Medicine and Biology. 36(12) (2010) 2018–2026.
[10] C. Y. Chang, H. Y. Liu, C. H. Tseng, and S. R. Shih, Computer-Aided Diagnosis for Thyroid Graves’ Disease in Ultrasound Images, Biomedical Engineering (Singapore). 22(2) (2010) 91–99.
[11] J. Martínez-Más, A. Bueno-Crespo, S. Khazendar, M. Remezal-Solano, J. P. Martínez-Cendán, et al., Evaluation of Machine Learning Methods with Fourier Transform Features for Classifying Ovarian Tumors Based on Ultrasound Images, Plos One. 14(7) (2019) e0219388.
[12] M. Lu, Z. Fan, B. Xu, L. Chen, X. Zheng, et al., Using Machine Learning to Predict Ovarian Cancer, International Journal of Medical Informatics. 141(104195) (2020).
[13] M. A. Rahman, R. C. Muniyandi, K. T. Islam and M. M. Rahman, Ovarian Cancer Classification Accuracy Analysis using 15-Neuron Artificial Neural Networks Model, In 2019 IEEE Student Conference on Research and Development (Scored). (2019).
[14] S. Ma, L. Sigal and S. Sclaroff, Learning Activity Progression in LSTMS for Activity Detection and Early Detection, In 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). (2016).
[15] A. C. Costa, H. C. R. Oliveira, J. H. Catani, N. de Barros, C. F. E. Melo, et al., Data Augmentation for Detection of Architectural Distortion in Digital Mammography Using Deep Learning Approach, Arxiv [Cs.Cv]. (2018).
[16] A. Krizhevsky, I. Sutskever, and G. E. Hinton, Imagenet Classification with Deep Convolutional Neural Networks, Communications of the ACM. 60(6) (2017) 84–90.
[17] H. R. Roth, L. Lu, A. Seff, K. M. Cherry, J. Hoffman, et al., A New 2.5D Representation for Lymph Node Detection using Random Sets of Deep Convolutional Neural Network Observations, Medical Image Computing and Computer-Assisted Intervention. 17(1) (2014) 520–527.
[18] R. M. Menchón-Lara, J. L. Sancho-Gómez, and A. Bueno-Crespo, Early-Stage Atherosclerosis Detection using Deep Learning Over Carotid Ultrasound Images, Applied Soft Computing. 49 (2016) 616–628.
[19] F. A. Spanhol, L. S. Oliveira, C. Petitjean, and L. Heutte, Breast Cancer Histopathological Image Classification Using Convolutional Neural Networks, International Joint Conference on Neural Networks. (2016).
[20] W. Li, P. Cao, D. Zhao and J. Wang, Pulmonary Nodule Classification with Deep Convolutional Neural Networks on Computed Tomography Images, Computational and Mathematical Methods in Medicine. 2016 (2016) 6215085.
[21] K. Simonyan and A. Zisserman, Very Deep Convolutional Networks for Large-Scale Image Recognition, Arxiv [Cs.CV]. (2014).
[22] C. Szegedy, W. Liu, Y. Jia, P. Sermanet, S. Reed et al., Going Deeper with Convolutions, Arxiv [Cs.CV]. (2014).
[23] K. He, X. Zhang, S. Ren, and J. Sun, Deep Residual Learning for Image Recognition, Arxiv [Cs.CV]. (2015).
[24] A. G. Howard, M. Zhu, B. Chen, D. Kalenichenko, W. Wang, et al., Mobilenets: Efficient Convolutional Neural Networks for Mobile Vision Applications, Arxiv [Cs.CV]. (2017).
[25] G. Huang, Z. Liu, L. Van der Maaten and K. Q. Weinberger, Densely Connected Convolutional Networks, Arxiv [cs.CV]. (2016).
[26] K. Jung, H. Park and W. Hwang, Deep Learning for Medical Image Analysis: Applications to Computed Tomography and Magnetic Resonance Imaging, Hanyang Medical Reviews. 37(2) (2017) 61-70.
[27] I. R. Haque and J. Neubert, Deep Learning Approaches to Biomedical Image Segmentation, Informatics in Medicine Unlocked. 18 (2020) 100297.
[28] L. Guo, A. Wu, Y. Wang, L. Zhang, H. Chai, et al., Deep Learning-Based Ovarian Cancer Subtypes Identification Using Multi-Omics Data, Biodata Mining. 13(1) (2020) 10-22.
[29] R. M. Ghoniem, A. D. Algarni, B. Refky and A. A. Ewees, Multi-Modal Evolutionary Deep Learning Model for Ovarian Cancer Diagnosis, Symmetry. 13(4) (2021) 643.
[30] K. Sone, Y. Toyohara, A. Taguchi, Y. Miyamoto, M. Tanikawa, et al., Application of Artificial Intelligence in Gynecologic Malignancies: A Review Journal of Obstetrics and Gynaecology Research. 47(8) (2021) 2577-2585.
[31] Genomic Data Commons Data Portal, Cancer.gov. [Online]. Available: www.portal.gdc.cancer.gov
[32] K.Kasture, Ovarian Cancer & Subtypes Dataset Histopathology, Mendeley. (2021).
[33] (2021). K. kasture, Kokilakasture / ovarian cancer prediction, [Online]. Available: www.github.com/kokilakasture/OvarianCancerPrediction.